Manufacturer Information

Name

Fisher Scientific

Address

One Reagent Lane
Fair Lawn , NJ 07410

Phone

201-796-7100

Effective Date

2007-05-16

Signal Word

WARNING

Hazard Statements

• Causes eye, skin, and respiratory tract irritation. Excessive exposure may cause liver and kidney damage. May cause cancer based on animal studies. May cause lung damage. Material is a solid at room temperature that melts upon moderate heating into a combustible liquid with a flash point below 200°F(93.3°C). Sublimes (goes directly from solid to vapor form) readily at room temperature. Target Organs: Kidneys, liver, lungs, respiratory system, eyes, skin.

Precautionary Statements

• Potential Health Effects Eye: Causes eye irritation. Exposure to high vapor concentrations may cause irritation. Solid particles of pDCB are reported to be painful to the eyes. Skin: Solid produces burning sensation when held in contact with the skin, but irritation is slight. A 69-yearold man contacting p-DCB in a treated chair developed skin lesions including swelling and discoloration; kidney damage also was reported. (Documentation of the TLV) Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. Inhalation: Causes respiratory tract irritation. May cause liver and kidney damage. Inhalation of vapors causes irritation of eyes, throat, and skin. Exposure may cause anorexia, nausea, vomiting, weight loss and hepatic necrosis with jaundice. Exposure may cause headache and rhinitis (inflammation of the mucous membrane of the nose). Signs and symptoms of overexposure listed by supplier include headache, dizziness/incoordination, nausea/vomiting, loss of consciousness, vertigo, confusion, anxiety, labored breathing, drowsiness. Chronic: Possible cancer hazard based on tests with laboratory animals. May cause anemia and other blood cell abnormalities. Chronic inhalation may lead to decreased pulmonary function. Animal studies indicate that the product may affect the liver and kidneys. Prolonged inhalation studies in animals produced lung effects. A NIEHS study examined the relationship between blood concentration of 1,4-DCB and lung function measurements in 953 adult humans and found that 1,4-DCB was associated with reduced lung function. The impaired function occurred even when adults' history of smoking was considered.

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