Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
109-99-9	Tetrahydrofuran	>=99.8%	203-726-8

Hazard Symbols: XI F
Risk Phrases: 11 19 36/37

Section 3 - Hazards Identification

Appearance: APHA: 5 max clear liquid. Flash Point: -21 deg C. Hygroscopic (absorbs moisture from the air).
Target Organs: Kidneys, central nervous system, liver, respiratory system, eyes.


Potential Health Effects
Eye: Contact with eyes may cause severe irritation, and possible eye burns. Vapors may cause eye irritation. Contact may cause ulceration of the conjunctiva and cornea.
Skin: May cause skin irritation. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis.
Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation.
Chronic: Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. May cause liver and kidney damage.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: Vapors can travel to a source of ignition and flash back. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Forms peroxides of unknown stability. Flammable liquid and vapor.
Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective.
Flash Point: -21 deg C ( -5.80 deg F)
Autoignition Temperature: 215 deg C ( 419.00 deg F)
Explosion Limits, Lower:1.50 vol %
Upper: 12.00 vol %
NFPA Rating: 2 - health, 3 - flammability, 1 - instability

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to dilute spill to a non-flammable mixture. Remove all sources of ignition.

Section 7 - Handling and Storage

Handling: Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Prevent build up of vapors to explosive concentration.
Storage: Keep away from heat, sparks, and flame. Store in a cool place in the original container and protect from sunlight. Keep from contact with oxidizing materials. Flammables-area. Regularly check inhibitor levels to maintain peroxide levels below 1%.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use adequate ventilation to keep airborne concentrations low.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Tetrahydrofuran	200 ppm TWA; 250 ppm STEL	200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH	200 ppm TWA; 590 mg/m3 TWA

OSHA Vacated PELs: Tetrahydrofuran: 200 ppm TWA; 590 mg/m3 TWA
Personal Protective Equipment
Eyes: Not available.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: A NIOSH/MSHA approved or European Standard EN 149 air purifying respirator with an organic vapor cartridge or canister may be permissible under certain circumstances where airborne concentrations are expected.

Section 9 - Physical and Chemical Properties

Physical State: Clear liquid
Appearance: APHA: 5 max
Odor: fruity odor
pH: Not available.
Vapor Pressure: 200 mbar @20 deg C
Vapor Density: 0.096 lbs/ft3
Evaporation Rate:8 (n-Butyl Acetate=1)
Viscosity: 0.55 cP 20 deg C
Boiling Point: 66 deg C @ 760.00mm Hg
Freezing/Melting Point:-108.4 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:.8880g/cm3
Molecular Formula:Not available.
Molecular Weight:72.11

Section 10 - Stability and Reactivity

Chemical Stability: Prolonged exposure to air and sunlight may form unstable peroxides.
Conditions to Avoid: Prolonged exposure to air and sunlight may form unstable peroxides., incompatible materials, light, exposure to moist air or water.
Incompatibilities with Other Materials: Sodium hydroxide, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), oxidizing agents (strong, e.g. bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), potassium hydroxide, bromine, metal halides.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.

Section 11 - Toxicological Information

RTECS#:
CAS# 109-99-9: LU5950000
LD50/LC50:
CAS# 109-99-9:
Inhalation, rat: LC50 = 21000 ppm/3H;
Oral, rat: LD50 = 1650 mg/kg;
Carcinogenicity:
CAS# 109-99-9: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No data available.
Teratogenicity: No data available.
Reproductive Effects: inh-rat TCL0: 5000 pppm/6H (6-19D preg)inh-mus TCL0: 1800 ppm/6H (6-17D preg)(see RTECS)
Neurotoxicity: No data available.
Mutagenicity: mmo-esc: 1 µmol/l(see RTECS)
Other Studies: See actual entry in RTECS for complete information. The toxicological properties have not been fully inve stigated.

Section 12 - Ecological Information

Ecotoxicity: No data available. Blue-green algae, growth inhibition microcystis=225 mg/L (PH=7);Protozoa, cell multiplication inhibition test=858 mg/L.(See also Dictionary of Substances and Their Effects 1992).
Environmental: In air, THF photodegrades by reaction with hydroxyl radicals with an estimated half-life of hours to a few days . It is soluble and expected to wash out in rain. In water, its fate is uncertain. Base on very limited evidence, THF is expected to biodegrade and not absorb into sediment. Tests in distilled water showed THF to last as follows: 0.5 mg/L for 1 to 2 days , 5 mg/L for 6 to 8 days, and 10 mg/L for 10 days.(See also Dictionary of Substances and Their Effects 1992).
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 109-99-9: waste number U213 (Ignitable waste).

Section 14 - Transport Information

	US DOT	IATA	RID/ADR	IMO	Canada TDG
Shipping Name:	No information available.				No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 109-99-9 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA

CERCLA Hazardous Substances and corresponding RQs
CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 109-99-9: acute, flammable, reactive.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 109-99-9 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XI F
Risk Phrases:
R 11 Highly flammable.
R 19 May form explosive peroxides.
R 36/37 Irritating to eyes and respiratory system.

Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static
discharges.

WGK (Water Danger/Protection)
CAS# 109-99-9: 1
Canada - DSL/NDSL
CAS# 109-99-9 is listed on Canada's DSL List.
Canada - WHMIS
WHMIS: Not available.
Canadian Ingredient Disclosure List
CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 109-99-9: OEL-AUSTRALIA:TWA 200 ppm (590 mg/m3);STEL 250 ppm (7
35 mg/m3) OEL-BELGIUM:TWA 200 ppm (590 mg/m3);STEL 250 ppm (738 mg/m3
) OEL-DENMARK:TWA 200 ppm (590 mg/m3) OEL-FINLAND:TWA 100 ppm (290 m
g/m3);STEL 150 ppm (440 mg/m3) OEL-FRANCE:TWA 200 ppm (590 mg/m3) OE
L-GERMANY:TWA 200 ppm (590 mg/m3) OEL-HUNGARY:TWA 200 mg/m3;STEL 400
mg/m3 OEL-JAPAN:TWA 200 ppm (590 mg/m3) OEL-THE NETHERLANDS:TWA 200
ppm (590 mg/m3) OEL-THE PHILIPPINES:TWA 200 ppm (590 mg/m3) OEL-RUSS
IA:TWA 200 ppm;STEL 100 mg/m3 OEL-SWEDEN:TWA 100 ppm (300 mg/m3);STEL
150 ppm (450 mg/m3) OEL-SWITZERLAND:TWA 200 ppm (590 mg/m3);STEL 100
0 ppm OEL-TURKEY:TWA 200 ppm (590 mg/m3) OEL-UNITED KINGDOM:TWA 200
ppm (590 mg/m3);STEL 250 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA
check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TL
V

Section 16 - Additional Information

MSDS Creation Date: 6/24/2003
Revision #0 Date: Original.

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.