Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
108-94-1	Cyclohexanone	>98	203-631-1

Section 3 - Hazards Identification

Appearance: clear, colorless to pale yellow liquid. Flash Point: 44 deg C.
Warning! Harmful if absorbed through the skin. May cause severe eye irritation and possible injury. Flammable liquid and vapor. Harmful if inhaled. Causes skin and respiratory tract irritation. May be harmful if swallowed. May cause central nervous system depression. May cause liver and kidney damage.
Target Organs: Kidneys, central nervous system, liver, respiratory system, eyes, skin.


Potential Health Effects
Eye: May result in corneal injury. Vapors may cause eye irritation. Contact produces irritation, tearing, and burning pain. Undiluted cyclohexanone placed in the eyes of rabbits caused marked irritation and some corneal injury.
Skin: Causes skin irritation. Harmful if absorbed through the skin. Not expected to cause an allergic skin reaction. Cyclohexanone was not a sensitizer in the guinea pig maximization test and the mouse ear swelling test. There has been one case report of sensitization to cyclohexanone itself in a patient using a PVC adhesive composed of 100% cyclohexanone; patch testing confirmed the sensitization.
Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
Inhalation: Causes respiratory tract irritation. May cause liver and kidney damage. Inhalation overexposure may lead to central nervous system depression, producing effects such as dizziness, headache, confusion, incoordination, nausea, weakness, and loss of consciousness. Extreme exposures may cause other CNS effects including death. Cyclohexanone has caused damage to the liver and kidneys in rabbits exposed by inhalation to an airborne concentration of 190 ppm.
Chronic: Prolonged or repeated skin contact may cause defatting and dermatitis. Prolonged exposure may cause non-specific nervous system effects. Animal studies indicate that the product may affect the liver and kidneys.

Section 4 - First Aid Measures

Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Cyclohexanol in urine can be useful in diagnosis.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media: Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. For small fires, use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam.
Flash Point: 44 deg C ( 111.20 deg F)
Autoignition Temperature: 420 deg C ( 788.00 deg F)
Explosion Limits, Lower:1.10 vol %
Upper: 9.4 vol %
NFPA Rating: (estimated) Health: 2; Flammability: 2; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Provide ventilation. Use only non-sparking tools and equipment.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame. Avoid breathing vapor or mist.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Cyclohexanone	20 ppm TWA; 50 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute	25 ppm TWA; 100 mg/m3 TWA 700 ppm IDLH	50 ppm TWA; 200 mg/m3 TWA

OSHA Vacated PELs: Cyclohexanone: 25 ppm TWA; 100 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: clear, colorless to pale yellow
Odor: Acetone or peppermint odor
pH: Not applicable.
Vapor Pressure: 4.33 mm Hg @ 25 deg C
Vapor Density: 3.4 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 155 deg C @ 760 mm Hg
Freezing/Melting Point:-47 deg C
Decomposition Temperature:Not available.
Solubility: Slightly soluble.
Specific Gravity/Density:.9478 @ 20°C
Molecular Formula:C6H10O
Molecular Weight:98.14

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, amines, nitric acid, alkalies.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information

RTECS#:      
CAS# 108-94-1: GW1050000
LD50/LC50:
CAS# 108-94-1:
     Draize test, rabbit, eye: 20 mg Severe;
     Draize test, rabbit, eye: 250 ug/24H Severe;
     Inhalation, mouse: LC50 = 2375 mg/m3;
     Inhalation, rat: LC50 = 8000 ppm/4H;
     Inhalation, rat: LC50 = 19000 mg/m3;
     Oral, mouse: LD50 = 1400 mg/kg;
     Oral, rat: LD50 = 1620 uL/kg;
     Oral, rat: LD50 = 1800 mg/kg;
     Skin, rabbit: LD50 = 1 mL/kg;
.

Carcinogenicity:
CAS# 108-94-1:

• ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans
  
• California: Not listed.
  
• NTP: Not listed.
  
• IARC: Not listed.