BRISTOL-MYERS SQUIBB, PHARMACEUTICAL GRP -- PENICILLIN G POTASSIUM FOR INJECTION (1,000,000; 5,000,000;  -- 6850-00F034178
<pre>=====================  Product Identification  =====================

Product ID:PENICILLIN G POTASSIUM FOR INJECTION (1,000,000; 5,000,000;
MSDS Date:10/29/1992
FSC:6850
NIIN:00F034178
=== Responsible Party ===
Company Name:BRISTOL-MYERS SQUIBB, PHARMACEUTICAL GRP
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Info Phone Num:800-332-2056/908-519-2385
Emergency Phone Num:201-519-2885/609-921-4081
Preparer's Name:DR E HAYES
CAGE:BRIST
=== Contractor Identification ===
Company Name:BRISTOL-MYERS SQUIBB PHARMACEUTICAL GROUP
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:908-519-2385
CAGE:BRIST
Company Name:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD  BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:609-921-4081
CAGE:4T649

=============  Composition/Information on Ingredients  =============

Ingred Name:PENICILLIN G POTASSIUM
CAS:113-98-4
RTECS #:XH9700000
Fraction by Wt: 95.35%

Ingred Name:SODIUM CITRATE
CAS:144-33-2
RTECS #:GE7580000
Fraction by Wt: >1%

Ingred Name:CITRIC ACID
CAS:77-92-9
RTECS #:GE7350000
Fraction by Wt: <1%

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50 (RAT): 6,700 MG/KG
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ANAPHYLAXIS: DIFFICULTY
    BREATHING/RESPIRATORY DISTRESS, MAY BE FATAL. ADVERSE HEMATOLOGIC
    EFFECTS: HEMOLYTIC ANEMIA/NEUTROPENIA/LEUKOPENIA & THROMBOCYTOPENIA
    WHEN HIGH DOSES WERE  ADMIN. THRU IV. INHA LATION/SKIN/EYES:
    ALLERGIC REACTIONS, ADVERSE RENAL EFFECTS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:HYPERSENSITIVITY REACTIONS:
    RASH/FEVER/WHEEZING/EOSINOPHILIA/PRURITUS/CHILLS & MYALGIA.
    INGESTED: NAUSEA/VOMITING/EPIGASTRIC DISTRESS/LOOSE STOOLS/DIARRHEA
    & FLATULENCE. EYES: TEARING/REDNESS/SWELLING /ALLERGIC REACTION.
Medical Cond Aggravated by Exposure:GASTROINTESTINAL
    DISEASE/HEPATIC/HEMATOLOGIC & RENAL DISORDERS. HYPERSENSITIVITY TO
    ANY PENICILLIN/CEPHALOSPORIN.

=======================  First Aid Measures  =======================

First Aid:EYES: FLUSH W/WATER FOR 15-20 MIN. SKIN: WASH W/SOAP/WATER
    FOR 15-20 MIN. INGESTION: VOMITING MAY BE INDUCED IF CONSCIOUS & IF
    INGESTION WITHIN PAST 3 HOURS. NEVER INDUCE VOMITING TO AN
    UNCONSCIOUS PE RSON/EXPERIENCING CONVULSIONS. INHALATION: REMOVE TO
    FRESH AIR/GIVE OXYGEN/CPR IF NECESSARY. OBTAIN MEDICAL ATTENTION IN
    ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER
Fire Fighting Procedures:EVACUATE AREA. USE SCBA/FULL PROTECTIVE
    CLOTHING. MOVE CONTAINERS FROM FIRE AREA W/O RISK & COOL W/WATER.
    FIGHT FROM SAFE DISTANCE. DIVERT RUNOFF TO A SAFE AREA
Unusual Fire/Explosion Hazard:FINE DUST SUSPENDED IN AIR IN SUFFICIENT
    CONCENTRATION & IN THE PRESENCE OF AN IGNITION SOURCE MAY POSE A
    POTENTIAL EXPLOSION HAZARD.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR PROTECTIVE CLOTHING. SWEEP ONTO
    PAPER/PLACE INTO A FIBER DRUM FOR DISPOSAL. VENTILATE &
    DECONTAMINATE AREA AFTER MATERIAL PICK UP.AVOID SKIN/EYE CONTACT
    W/POWDER & INHALATION. POWDER MAY BE WETTE D TO MINIMIZE DUST
    GENERATION. USE DUST/MIST RESP.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AT ROOM TEMP, IN HERMETICALLY
    SEALED CONTAINERS. UNDER NORMAL CONDITIONS THIS MATERIAL IS HANDLED
    IN CLOSED VIALS.
Other Precautions:IF VIALS BREAK, MATERIAL HAS SPILLED. AVOID SKIN/EYE
    CONTACT & INHALATING POWDER. USE CHEMICAL SAFETY GOGGLES, DUST/MIST
    RESPIRATOR, GOWN, HAIR/SHOE COVERS & LATEX GLOVES.

=============  Exposure Controls/Personal Protection  =============

Protective Gloves:LATEX
Eye Protection:REQUIRED
Work Hygienic Practices:WASH HANDS/FACE AFTER HANDLING THIS COMPOUND.
    WASH/LAUNDER CONTAMINATED CLOTHING BEFORE REUSE.
Supplemental Safety and Health
PRODUCT IS CONTAINED IN CLOSED/SEALED VIALS. AT NORMAL CONDITIONS,
    PERSONS WOULDN'T BE EXPOSED TO POWDER. WHEN PREPARED, IN A CLINICAL
    SETTING, STERILE WATER FOR INJECTION IS ADDED TO THE VIAL CONTAIN
    ING PENICILLIN G SODIUM. THE SOLUTION IS INTENDED FOR
    INTRAMUSCULAR/INTRAVENOUS INJECTION UNDER PHYSICIANS CARE.

==================  Physical/Chemical Properties  ==================

Solubility in Water:COMPLETE
Appearance and Odor:FINE/WHITE/CRYSTALLINE POWDER, PRACTICALLY FREE
    FROM VISIBLE IMPURITIES/ODORLES

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
ACIDS/ALKALI HYDROXIDES/GLYCERIN/OXIDIZING AGENTS
Stability Condition to Avoid:ELEVATED TEMP, IGNITION SOURCES
Conditions to Avoid Polymerization:CO, CO2, OXIDES OF NITROGEN, SULFUR,
    NITROGEN OXIDES & SULFUR OXIDES

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
    FEDERAL REGULATIONS.

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