CALBIOCHEM -- TRYPSIN, BOVINE PANCREAS, 6502 -- 6550-00N092496 
=====================  Product Identification  =====================

Product ID:TRYPSIN, BOVINE PANCREAS, 6502
MSDS Date:11/11/1998
FSC:6550
NIIN:00N092496
Status Code:A
=== Responsible Party ===
Company Name:CALBIOCHEM
Box:12087
City:LA JOLLA
State:CA
ZIP:92039-2087
Country:US
Info Phone Num:800-854-3417; 619-450-5558
Emergency Phone Num:202-783-7616 (INTERNATL)
Chemtrec Ind/Phone:(800)424-9300
CAGE:29089
=== Contractor Identification ===
Company Name:CALBIOCHEM
Box:12087
City:LA JOLLA
State:CA
ZIP:92039-2087
Country:US
Phone:619-450-5558; 800-854-3417
CAGE:29089

=============  Composition/Information on Ingredients  =============

Ingred Name:TRYPSIN
CAS:9002-07-7
RTECS #:YN5075000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50:(ORAL,RAT) >5 G/KG & TOX INFO
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:MAY BE HARMFUL BY INGESTION,
    INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL CAUSES SEVERE
    IRRITATION TO THE EYES, SKIN, MUCOUS MEMBRANES, AND THE UPPER
    RESPIRATORY TRACT. PROLONGED OR REPEATED EXPOSU RE MAY CAUSE
    ALLERGIC REACTIONS IN SENSITIVE INDIVIDUALS.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

First Aid:SKIN: WASH IMMEDIATELY WITH COPIOUS AMOUNTS OF WATER FOR AT
    LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH
    BEFORE WEARING. CONSULT MD. EYES: FLUSH IMMEDIATELY WITH COPIOUS
    AMOUNTS O F WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING
    BY SEPARATING EYELIDS WITH FINGERS. CONSULT MD. INHALATION: REMOVE
    TO FRESH AIR AND MONITOR BREATHING. IF BREATHING BECOMES DIFFICULT,
    GIVE OX YGEN AND CONSULT MD. IF BREATHING STOPS, GIVE ARTIFICIAL
    RESPIRATION AND CONSULT MD. INGESTION: WASH MOUTH OUT WITH WATER
    AND CONSULT LOCAL POISON CENTER AND MD.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
    ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
    EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
    TOXIC GASES.

==================  Accidental Release Measures  ==================

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
    RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER
    GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
    DUST. HOLD FOR APPROPRIATE DIS POSAL. WASH SPILL SITE AND VENTILATE
    AREA AFTER MATERIAL PICKUP IS COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
    A (+4C) REFRIGERATOR. PROTECT FROM MOISTURE. MATERIAL IS HARMFUL
    AND AN IRRITANT. MATERIAL MAY CAUSE SENSITIZATION. AVOID CONTACT
    WITH MATERIAL. AVOID PROLONGED  OR REPEATED EXPOSURE. DO NOT
    BREATHE DUST. AVOID CONTACT WITH SKIN AND EYES.
Other Precautions:MAY CAUSE SENSITIZATION BY INHALATION AND SKIN
    CONTACT. IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL
    ADVICE IMMEDIATELY. MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED,
    EXPERIENCED PROFESSION ALS.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH
    FACESHIELD .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
    WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
MFR'S INFO: MFR'S FAX #: (619) 452-3552; MFR'S INFO ON INGS: MOLECULAR
    WEIGHT: 23, 281. -- PHYSICAL AND CHEMICAL PROPERTIES: SOLUBILITY:
    SOLUBLE IN HCL, NEUTRAL BUFFERS.

==================  Physical/Chemical Properties  ==================

Solubility in Water:SOLUBLE & SEE SUPP DATA
Appearance and Odor:SALT-FREE SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NOT APPLICABLE.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
    TOXIC GASES INCLUDING CARBON MONOXIDE AND CARBON DIOXIDE.

===================  Toxicological Information	===================

Toxicological Information:TOX DATA & REFERENCES: LD50:(ORAL,RAT) >5
    G/KG 1990; LD50:(ORAL,MUS) 1450 MG/KG; LD50:(IPR,RAT) >51 MG/KG
    1990; LD50:(IVN,MUS) 11,100 UG/KG; LD50:(IVN,RBT) 2200 UG/KG;
    LD50:(IMS,RAT) 200 UG/KG 1990; L D50:(IMS,MUS) 105 MG/KG 1990.
    "DRUGS IN JAPAN (ETHICAL DRUGS)". -, 744. LD50:(IPR,MUS) 100 MG/M3
    1982; LD50:(IVN,RAT) 36 MG/KG 1982. "FARMAKOLOGIYA I TOKSIKOLOGIYA
    (MOSCOW)". 45(6), 78. GENETIC DATA &  REFERENCES: FBR; HAM; DOSE:
    100 PPM DNA DMG 1970. "COLLECTION OF PAPERS PRESENTED AT ANNUAL
    SYMPOSIUM ON FUNDAMENTAL CANCER RESEARCH". 23, 346. REFER TO
    (RTECS) FOR DEFINITION OF ABBREVIATIONS USED I N TEXT & FOR ADDNL
    INFO. (OTHER INFO)

=====================  Ecological Information  =====================

Ecological:NO INFORMATION AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:COUNTRY, FEDERAL, STATE & LOCAL REGS ARE VARIED
    AND CHANGE FREQUENTLY. FOR THIS REASON, MFR RECOMMENDS THAT YOU
    CONT YOUR LOCAL DEPARTMENT OF HEALTH SERVICES FOR INFO ON THE
    DISPOSAL OF THIS PROD/ARRA NGE FOR DISPOSAL BY A LICENSED DISPOSAL
    COMPANY.  DISPOSE OF IN ACCORDANCE WITH FEDERAL, STATE AND L OCAL
    REGULATIONS .

===================  MSDS Transport Information  ===================

Transport Information:UN NUMBER: N/A. PROPER SHIPPING NAME: N/A. IATA
    CLASS: N/A. IATA PACKING GROUP: N/A.

=====================  Regulatory Information  =====================

Federal Regulatory Information:REGULATORY INFORMATION: XI, XN. RISK
    PHRASES: R20/21/22: HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND
    IF SWALLOWED. R36/37/38: IRRITATING TO EYES, RESPIRATORY SYSTEM AND
    SKIN. R42: MAY CAUSE SENSIT IZATION BY INHALATION AND SKIN CONTACT.
    SAFETY PHRASES: S22: DO NOT BREATHE DUST. S24/25: AVOID CONTACT
    WITH SKIN AND EYES. S26: IN CASE OF CONTACT WITH EYES, RINSE
    IMMEDIATELY WITH PLENTY OF WATER AN D SEEK MEDICAL ADVICE.
    S36/37/39: WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.  S45:IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK
    MEDICAL ADVICE IMMEDIATELY.
State Regulatory Information:

=======================  Other Information  =======================

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